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Influence of antibiotic therapy on serum levels of reactive oxygen species in ovariectomized bitches.
- Source :
-
Journal of veterinary pharmacology and therapeutics [J Vet Pharmacol Ther] 2008 Feb; Vol. 31 (1), pp. 18-21. - Publication Year :
- 2008
-
Abstract
- This study was conducted on 60 ovariectomized bitches. The objectives were to measure the mean reactive oxygen species (ROS) concentrations before, during and after surgery, and to investigate the effect of the administration of five different antibiotic treatments: amoxicillin, benzylpenicillin/dihydrostreptomycin, sulfametazine/sulfamerazine/sulfathiazole, enrofloxacin, lincomycin/spectinomycin. The first value recorded represented the mean ROS concentration in anestral bitches and constitutes a reference level with which to compare the subsequent measurements. After premedication, induction of anesthesia and during maintenance and surgery, ROS serum concentrations showed constant values until the end of surgery. After surgery and during antibiotic administration, an increase in ROS concentration occurred, which differed among the five groups in relation to the antibiotics employed. The lowest increases occurred in the groups treated with the combination of lincomycin/spectinomycin, and with amoxicillin; whereas the highest increases were detected in the group treated with enrofloxacin. The three other antibiotics showed an intermediate level of influence on oxidative status.
- Subjects :
- Amoxicillin administration & dosage
Amoxicillin pharmacology
Anesthesia, General veterinary
Animals
Anti-Bacterial Agents administration & dosage
Dogs blood
Dogs surgery
Enrofloxacin
Female
Fluoroquinolones administration & dosage
Fluoroquinolones pharmacology
Lincomycin administration & dosage
Lincomycin pharmacology
Ovariectomy veterinary
Penicillin G administration & dosage
Penicillin G pharmacology
Postoperative Care veterinary
Preoperative Care veterinary
Sulfamethazine administration & dosage
Sulfamethazine pharmacology
Surgical Wound Infection prevention & control
Anti-Bacterial Agents pharmacology
Dog Diseases prevention & control
Dogs physiology
Reactive Oxygen Species blood
Surgical Wound Infection veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 0140-7783
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of veterinary pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 18177314
- Full Text :
- https://doi.org/10.1111/j.1365-2885.2007.00919.x