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Risk of venous thrombosis in patients with pancreatic adenocarcinoma.
- Source :
-
Gastroenterologie clinique et biologique [Gastroenterol Clin Biol] 2007 Dec; Vol. 31 (12), pp. 1139-42. - Publication Year :
- 2007
-
Abstract
- Aim: To estimate the risk of venous thrombosis associated with pancreatic adenocarcinoma and its consequences on treatment and survival.<br />Patients and Methods: We retrospectively analyzed a cohort of 90 patients (49 males, 41 females - median age: 67 years [range: 37-94]). Pancreatic adenocarcinoma was histologically proved in 72 patients (81%) and was metastatic in 49 patients (54.4%). A venous thrombosis was observed in 24 patients (26.7%). A pulmonary embolism occurred in 4 patients with 2 deaths. The risk of venous thrombosis was significantly reduced by the use of anti-thrombotic prophylaxis (HR: 0.03 [95CI: 0.003-0.27]) and increased among patients with a biological inflammatory syndrome (HR: 9.0 [95CI: 2.30-34.4]) and metastatic disease (HR: 4.4 [95CI: 1.1-17.9]). Overall survival was not different between patients with (6.6 months) or without (6.1 months) venous thrombosis.<br />Conclusion: The risk of venous thrombosis is important and may delay the treatment in patients with advanced pancreatic carcinoma. Some patients with high risk of venous thrombosis may benefit from a prophylactic anticoagulant treatment.
- Subjects :
- Adenocarcinoma secondary
Adult
Aged
Aged, 80 and over
Anticoagulants therapeutic use
Catheters, Indwelling
Cause of Death
Cohort Studies
Female
Fibrinolytic Agents therapeutic use
Heparin, Low-Molecular-Weight therapeutic use
Humans
Inflammation
Male
Middle Aged
Pulmonary Embolism etiology
Retrospective Studies
Risk Factors
Survival Rate
Venous Thrombosis prevention & control
Adenocarcinoma complications
Pancreatic Neoplasms complications
Venous Thrombosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0399-8320
- Volume :
- 31
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Gastroenterologie clinique et biologique
- Publication Type :
- Academic Journal
- Accession number :
- 18176374
- Full Text :
- https://doi.org/10.1016/s0399-8320(07)78352-5