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3-drug synergistic interactions of small molecular inhibitors of hepatitis C virus replication.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2008 Jan 01; Vol. 197 (1), pp. 42-5. - Publication Year :
- 2008
-
Abstract
- Small molecular inhibitors of hepatitis C virus (HCV) replication provide remarkable potency, but the rapid selection of resistance mutations will require that these agents be used in combination for clinical treatment. Using a model HCV replicon system, we have extended prior in vitro studies of double combinations of candidate small molecular inhibitors to studies evaluating the simultaneous use of 3 agents. This was done in an effort to anticipate conditions that might ultimately be required clinically. We formally demonstrate synergistic antiviral activity with 3-drug combinations in this model, further supporting the concept of clinical investigations of combination therapy for HCV infection.
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 197
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18171283
- Full Text :
- https://doi.org/10.1086/524062