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[Isolation of bone morphogenetic protein from human osteosarcoma tissue].

Authors :
Kübler N
Urist MR
Source :
Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie [Dtsch Z Mund Kiefer Gesichtschir] 1991 Jul-Aug; Vol. 15 (4), pp. 258-64.
Publication Year :
1991

Abstract

Isolated from an osteosarcoma specimen from a 15-year-old girl and assayed by implantation, partly purified lyophilized bone morphogenetic protein (BMP) induced heterotopic ossification in the mouse quadriceps. The apparent molecular weight was 18 kDa. Osteosarcoma-derived BMP induced the same process of bone development as human BMP from normal bone matrix.

Subjects

Subjects :
Adolescent
Animals
Biological Assay
Bone Morphogenetic Proteins
Female
Growth Substances isolation & purification
Humans
Lung Neoplasms chemistry
Mice
Tibia
Bone Neoplasms chemistry
Lung Neoplasms secondary
Neoplasm Proteins isolation & purification
Osteogenesis
Osteosarcoma chemistry
Proteins isolation & purification

Details

Language :
German
ISSN :
0343-3137
Volume :
15
Issue :
4
Database :
MEDLINE
Journal :
Deutsche Zeitschrift fur Mund-, Kiefer- und Gesichts-Chirurgie
Publication Type :
Academic Journal
Accession number :
1816955

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Authors Abstract Subjects Details