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Regulation of translation is required for dendritic cell function and survival during activation.
- Source :
-
The Journal of cell biology [J Cell Biol] 2007 Dec 31; Vol. 179 (7), pp. 1427-39. - Publication Year :
- 2007
-
Abstract
- In response to inflammatory stimulation, dendritic cells (DCs) have a remarkable pattern of differentiation (maturation) that exhibits specific mechanisms to control antigen processing and presentation. Here, we show that in response to lipopolysaccharides, protein synthesis is rapidly enhanced in DCs. This enhancement occurs via a PI3K-dependent signaling pathway and is key for DC activation. In addition, we show that later on, in a manner similar to viral or apoptotic stress, DC activation leads to the phosphorylation and proteolysis of important translation initiation factors, thus inhibiting cap-dependent translation. This inhibition correlates with major changes in the origin of the peptides presented by MHC class I and the ability of mature DCs to prevent cell death. Our observations have important implications in linking translation regulation with DC function and survival during the immune response.
- Subjects :
- Animals
Cell Survival genetics
Cells, Cultured
Eukaryotic Initiation Factors genetics
Histocompatibility Antigens Class I metabolism
Immunity, Cellular genetics
Inflammation genetics
Inflammation metabolism
Lipopolysaccharides pharmacology
Lymphocyte Activation genetics
Male
Mice
Mice, Inbred C57BL
Phosphatidylinositol 3-Kinases metabolism
Signal Transduction physiology
Up-Regulation genetics
Antigen Presentation genetics
Cell Differentiation genetics
Codon, Terminator genetics
Dendritic Cells physiology
Eukaryotic Initiation Factors metabolism
Protein Biosynthesis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1540-8140
- Volume :
- 179
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 18166652
- Full Text :
- https://doi.org/10.1083/jcb.200707166