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Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin.
- Source :
-
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2008 Aug; Vol. 15 (8), pp. 630-4. Date of Electronic Publication: 2008 Mar 04. - Publication Year :
- 2008
-
Abstract
- The effects of alpha,beta-amyrin, a pentacyclic triterpene isolated from Protium heptaphylum was investigated on rat model of orofacial pain induced by formalin or capsaicin. Rats were pretreated with alpha,beta-amyrin (10, 30, and 100mg/kg, i.p.), morphine (5mg/kg, s.c.) or vehicle (3% Tween 80), before formalin (20 microl, 1.5%) or capsaicin (20 microl, 1.5 microg) injection into the right vibrissa. In vehicle-treated controls, formalin induced a biphasic nociceptive face-rubbing behavioral response with an early first phase (0-5 min) and a late second phase (10-20 min) appearance, whereas capsaicin produced an immediate face-rubbing (grooming) behavior that was maximal at 10-20 min. Treatment with alpha,beta-amyrin or morphine significantly inhibited the face-rubbing response in both test models. While morphine produced significant antinociception in both phases of formalin test, alpha,beta-amyrin inhibited only the second phase response, more prominently at 30 mg/kg, in a naloxone-sensitive manner. In contrast, alpha,beta-amyrin produced much greater antinociceptive effect at 100mg/kg in the capsaicin test, which was also naloxone-sensitive. These results provide first time evidence to show that alpha,beta-amyrin attenuates orofacial pain at least, in part, through a peripheral opioid mechanism but warrants further detailed study for its utility in painful orofacial pathologies.
- Subjects :
- Analgesics administration & dosage
Analgesics chemistry
Analgesics therapeutic use
Animals
Burseraceae chemistry
Dose-Response Relationship, Drug
Drug Administration Schedule
Male
Molecular Structure
Oleanolic Acid administration & dosage
Oleanolic Acid chemistry
Oleanolic Acid therapeutic use
Phytotherapy
Rats
Rats, Wistar
Capsaicin toxicity
Facial Pain chemically induced
Facial Pain prevention & control
Formaldehyde toxicity
Oleanolic Acid analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1618-095X
- Volume :
- 15
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18164607
- Full Text :
- https://doi.org/10.1016/j.phymed.2007.11.016