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Double-stranded RNA homopolymer poly(rC).poly(rG) for a new pH-sensitive drug carrier.
- Source :
-
Molecular pharmaceutics [Mol Pharm] 2008 Jan-Feb; Vol. 5 (1), pp. 162-4. Date of Electronic Publication: 2007 Dec 28. - Publication Year :
- 2008
-
Abstract
- Double-stranded RNA homopolymer poly(rC).poly(rG) has been used as a new pH-sensitive drug carrier. The poly(rC).poly(rG) had proton buffering capacity around pH 6, owing to protonation of cytosine, as determined by acid-base titration. By circular dichroism measurement, the protonation caused conformational change of the RNA. The poly(rC).poly(rG) and doxorubicin (Dox), as an anticancer drug, formed the complexes which released the drugs at endosomal pH. The resulting complex exhibited higher anticancer activity than the Dox alone. These results result suggest that the poly(rC).poly(rG) is a promising biopolymer for a new class of pH-sensitive drug carriers.
- Subjects :
- Antibiotics, Antineoplastic chemistry
Antibiotics, Antineoplastic pharmacology
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular metabolism
Cell Survival drug effects
Circular Dichroism
Doxorubicin chemistry
Doxorubicin pharmacology
Humans
Hydrogen-Ion Concentration
Liver Neoplasms drug therapy
Liver Neoplasms metabolism
Poly C chemistry
Poly G chemistry
RNA, Double-Stranded genetics
Tumor Cells, Cultured
Drug Carriers
Poly C metabolism
Poly G metabolism
Polymers chemistry
RNA, Double-Stranded chemistry
RNA, Double-Stranded metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1543-8384
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 18161943
- Full Text :
- https://doi.org/10.1021/mp7001076