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Relative influences of adjunctive topiramate and adjunctive lamotrigine on scanning and the effective field of view.
- Source :
-
Epilepsy research [Epilepsy Res] 2008 Feb; Vol. 78 (2-3), pp. 140-6. Date of Electronic Publication: 2007 Dec 21. - Publication Year :
- 2008
-
Abstract
- A subsample of 67 adult patients with partial seizures participating in a randomized, double-blind study comparing the cognitive effects of adjunctive lamotrigine (LTG) and adjunctive topiramate (TPM) was administered Performance On-Line (POL) in addition to a battery of neuropsychological tests at baseline, week 8 and week 16 of treatment. The POL is a self-administered computer task that measures scanning, divided-attention, and the effective field of view. Although the POL does not measure driving performance, POL scores are correlated with driving performance. The results show that adjunctive TPM, but not adjunctive LTG, negatively impacted cognition. Both simple target identification and divided-attention performance on POL were compromised in the TPM group but not in the LTG group. The relative POL impairment associated with chronic TPM treatment was similar to that observed with the acute effects of alcohol with a breath level of .045% or a low dose of alprazolam (0.5mg). Thus, driving-related visual and cognitive skills were compromised by adjunctive TPM treatment. Therapeutic doses of adjunctive TPM pose a potential risk of impaired scanning and divided-attention skills.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anticonvulsants therapeutic use
Cognition drug effects
Data Interpretation, Statistical
Double-Blind Method
Drug Therapy, Combination
Epilepsy drug therapy
Female
Fructose adverse effects
Fructose therapeutic use
Humans
Lamotrigine
Male
Middle Aged
Neuropsychological Tests
Seizures drug therapy
Seizures epidemiology
Topiramate
Triazines therapeutic use
Vision Disorders psychology
Visual Perception drug effects
Anticonvulsants adverse effects
Epilepsy complications
Fructose analogs & derivatives
Triazines adverse effects
Vision Disorders chemically induced
Visual Fields drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0920-1211
- Volume :
- 78
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Epilepsy research
- Publication Type :
- Academic Journal
- Accession number :
- 18155445
- Full Text :
- https://doi.org/10.1016/j.eplepsyres.2007.10.013