Preparation of [Arg-Gly-Asp]-[amino-poly(ethylene glycol)] hybrids and their inhibitory effect on experimental metastasis.

Authors :: Kawasaki K
Namikawa M
Yamashiro Y
Hama T
Mayumi T
Source :: Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 1991 Dec; Vol. 39 (12), pp. 3373-5.
Publication Year :: 1991
Abstract: Hybrids of a fibronectin-related tripeptide (Arg-Gly-Asp) and amino-poly(ethylene glycol) were prepared and their inhibitory effect on experimental metastasis in mice was examined. The hybrids exhibited a potent inhibitory effect on the metastasis of B16 melanoma BL6.

Subjects :: Amino Acid Sequence
Animals
Antineoplastic Agents pharmacology
Melanoma, Experimental drug therapy
Melanoma, Experimental pathology
Mice
Molecular Sequence Data
Oligopeptides pharmacology
Polyethylene Glycols pharmacology
Antineoplastic Agents chemical synthesis
Neoplasm Metastasis prevention & control
Neoplasms, Experimental drug therapy
Oligopeptides chemical synthesis
Polyethylene Glycols chemical synthesis

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