[The clinico-pathogenetic significance of general and local defense and injury factors in endometritis after cesarean section].

Analysis of phagocytosis parameters in uterine lochia and measurements of polyvalent proteinase inhibitor and alkaline phosphatase activities, as well as of lipid peroxidation parameters in uterine lochia are recommended for the early diagnosis of endometritis following a cesarean section. Local changes in the defense and injurious factors forerun the development of an inflammation in the uterine cavity whereas systemic changes develop after the manifestation of clinical symptoms of endometritis. The findings indicate that development of endometritis following an abdominal delivery may be prevented by routine therapy supplemented by thymalin and intrauterine metronidazole. Therapy of endometritis developing after cesarean section should include immunomodulators, chosen individually, and administered in combination with intrauterine contrycal.