Topical flunisolide treatment of perennial rhinitis: clinical and immunological effects.

Authors :: Paganelli R
Quinti I
di Sabatino A
d'Offizi GP
Scala E
Meglio P
Aiuti F
Source :: Allergologia et immunopathologia [Allergol Immunopathol (Madr)] 1991 Sep-Oct; Vol. 19 (5), pp. 194-6.
Publication Year :: 1991
Abstract: We studied the clinical and immunological effects of three months' treatment with intranasal flunisolide (100 micrograms daily) in 18 allergic patients with perennial rhinitis. 17 were hypersensitive to house dust mite and one to Parietaria pollen only. We found no significant changes in white blood cell count, serum levels of IgE and nasal IgA. However the treatment induced a marked improvement of clinical symptoms in all cases, and we observed a significant reduction of total IgE in nasal secretion. Flunisolide seems to exert this effect through its antiinflammatory action on the nasal mucosa.

Subjects :: Administration, Intranasal
Administration, Topical
Adolescent
Adult
Animals
Drug Evaluation
Female
Fluocinolone Acetonide administration & dosage
Fluocinolone Acetonide therapeutic use
Humans
Male
Mites
Pollen
Anti-Inflammatory Agents therapeutic use
Fluocinolone Acetonide analogs & derivatives
Rhinitis, Allergic, Perennial drug therapy

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