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Efficient C2 functionalisation of 2H-2-imidazolines.
- Source :
-
Organic & biomolecular chemistry [Org Biomol Chem] 2008 Jan 07; Vol. 6 (1), pp. 130-7. Date of Electronic Publication: 2007 Nov 08. - Publication Year :
- 2008
-
Abstract
- Alkylation and oxidation of 2H-2-imidazolines, followed by regioselective deprotection, thionation and microwave-assisted Liebeskind-Srogl reaction, efficiently led to 2-aryl-2-imidazolines as new analogues of p53-hdm2 interaction inhibitors (Nutlins).
Details
- Language :
- English
- ISSN :
- 1477-0520
- Volume :
- 6
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Organic & biomolecular chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18075657
- Full Text :
- https://doi.org/10.1039/b713065a