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[Alkaloid metabolites of mangrove endophytic fungus ZZF42 from the South China Sea].
- Source :
-
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials [Zhong Yao Cai] 2007 Aug; Vol. 30 (8), pp. 939-41. - Publication Year :
- 2007
-
Abstract
- Four compounds, apicidin (1), N-methylharman (2), cylo (Phe-Tyr) (3) and indole-3-acetic acid (4) were isolated from the mangrove endophytic fungus ZZF42 from the South China Sea. Their structures were elucidated by spectral data. Compound 1 was first isolated from the marine fungus. Compound 2 was firstly isolated from marine microorganism. Compound 1 exhibited selective in vitro cytotoxicity towards KB ahd KBv200 with IC50 values of less than 0.78 microg/ml.
- Subjects :
- Alkaloids chemistry
Alkaloids pharmacology
Antineoplastic Agents pharmacology
Cell Line, Tumor
Cell Survival drug effects
China
Fungi metabolism
Humans
Indoleacetic Acids chemistry
Indoleacetic Acids isolation & purification
Indoleacetic Acids pharmacology
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Molecular Structure
Nasopharyngeal Neoplasms pathology
Peptides, Cyclic chemistry
Peptides, Cyclic pharmacology
Alkaloids isolation & purification
Fungi chemistry
Peptides, Cyclic isolation & purification
Rhizophoraceae microbiology
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1001-4454
- Volume :
- 30
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Publication Type :
- Academic Journal
- Accession number :
- 18074839