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p53 Nuclear accumulation and Bcl-2 expression in contiguous adenomatous components of colorectal adenocarcinomas predict aggressive tumor behavior.
- Source :
-
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2008 Mar; Vol. 56 (3), pp. 305-12. Date of Electronic Publication: 2007 Dec 10. - Publication Year :
- 2008
-
Abstract
- For subsets of colorectal adenocarcinoma (CRC) patients, nuclear accumulation of p53 (p53(nac)) and Bcl-2 expression are prognostic indicators. To understand their role in the progression of CRC we evaluated 90 CRCs and their contiguous adenomatous components (CAdCs) for immunohistochemical expression of these markers. In general, p53(nac) and Bcl-2 expression was significantly increased when comparing normal colonic epithelia to CAdCs and CRCs. Thirteen (14%) CAdCs that demonstrated p53(nac) continued to express p53(nac) in their contiguous CRCs. A similar trend was observed in Bcl-2 expression in that the majority of CAdCs expressing Bcl-2 continued to express it in their matching CRCs (39/44). Patients whose CAdCs and their contiguous CRCs demonstrate p53(nac) had shorter median survival (35.9 months) than those patients whose CAdCs and CRCs did not (80.56 months). However, patients whose CAdCs had p53(nac) and lacked Bcl-2 expression had the lowest median survival (15.74 months) when compared with patients whose CAdCs did not demonstrate p53(nac) but had increased expression of Bcl-2 (71.77 months). These findings suggest that in those adenomas that demonstrate p53(nac) but lack Bcl-2 expression, their contiguous CRCs are more likely to be aggressive as they progress.
- Subjects :
- Adenocarcinoma diagnosis
Adenocarcinoma pathology
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor biosynthesis
Colorectal Neoplasms diagnosis
Colorectal Neoplasms pathology
Female
Humans
Immunohistochemistry
Male
Middle Aged
Predictive Value of Tests
Adenocarcinoma metabolism
Colorectal Neoplasms metabolism
Proto-Oncogene Proteins c-bcl-2 biosynthesis
Tumor Suppressor Protein p53 biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1554
- Volume :
- 56
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- Publication Type :
- Academic Journal
- Accession number :
- 18071066
- Full Text :
- https://doi.org/10.1369/jhc.7A7362.2007