Genetic association of preeclampsia to the inflammatory response gene SEPS1.

Authors :: Moses EK
Johnson MP
Tømmerdal L
Forsmo S
Curran JE
Abraham LJ
Charlesworth JC
Brennecke SP
Blangero J
Austgulen R
Source :: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2008 Mar; Vol. 198 (3), pp. 336.e1-5. Date of Electronic Publication: 2008 Feb 20.
Publication Year :: 2008
Abstract: Objective: The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia.<br />Study Design: A retrospective study in a large Norwegian case-control cohort compared maternal genotype and allele frequencies of the SEPS1 g.-105G>A polymorphism genotyped by SNPlex assay in preeclamptic (n = 1139) and control (n = 2269) women. Statistical significance was determined by chi2 and multivariate regression analyses.<br />Results: Women with preeclampsia were 1.34 times more likely to have the GA or AA genotype (P = .0039; 95% confidence interval [CI] 1.09 to 1.64) and 1.22 times more likely to carry the A allele (P = .023; odds ratio, 1.22; 95% CI, 1.02 to 1.46).<br />Conclusion: The A allele of the SEPS1-105G>A polymorphism is a significant risk factor for preeclampsia in this population.