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Comparison of acute non-haemolytic transfusion reactions in female and male patients receiving female or male blood components.
- Source :
-
Transfusion medicine (Oxford, England) [Transfus Med] 2007 Dec; Vol. 17 (6), pp. 455-65. - Publication Year :
- 2007
-
Abstract
- To study the relationship between antibodies detected in patients' and/or donors' sera and the clinical features of acute non-haemolytic transfusion reactions (ANHTRs), and to determine any gender-related difference. ANHTRs range from urticaria to transfusion-related acute lung injury (TRALI). Antibodies to human leukocyte antigen (HLA), granulocytes, platelets, and/or plasma proteins are implicated in some of the ANHTRs. A higher antibody positivity is expected for females than for males. A comparative study of ANHTRs for antibody positivity and their clinical features between females and males for both patients and donors is helpful for characterizing ANHTRs including TRALI more clearly, but such studies are few and outdated. Two hundred and twenty-three ANHTR cases reported by 45 hospitals between October 2000 and July 2005 were analysed. The patients and 196 donors of suspect blood products were screened for antibodies to HLA Class I, HLA Class II, granulocytes, and platelets. The patients were also screened for anti-plasma protein antibodies. The types and severity of ANHTR did not differ significantly between female and male patients. The frequency of the anti-HLA antibodies, but not that of the non-HLA antibodies, was significantly higher in females. Non-HLA antibodies were significantly associated with severe reactions in females. All the TRALI cases had predisposing risk factors for acute lung injury, and 60% of the cases showed anti-leucocyte antibodies. Although the anti-HLA antibodies were detected more frequently in females than males, no significant association of ANHTRs including TRALI with gender, not only for patients, but also for donors, could be shown in this study.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Anaphylaxis epidemiology
Anaphylaxis etiology
Anaphylaxis immunology
Antigens, Human Platelet immunology
Blood Donors
Blood Proteins immunology
Child
Child, Preschool
Female
Fever epidemiology
Fever etiology
Fever immunology
HLA Antigens immunology
Humans
Infant
Infant, Newborn
Isoantibodies blood
Male
Middle Aged
Plasma
Respiratory Distress Syndrome epidemiology
Respiratory Distress Syndrome etiology
Respiratory Distress Syndrome immunology
Risk Factors
Urticaria epidemiology
Urticaria etiology
Urticaria immunology
Blood Component Transfusion adverse effects
Sex Factors
Subjects
Details
- Language :
- English
- ISSN :
- 0958-7578
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Transfusion medicine (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18067650
- Full Text :
- https://doi.org/10.1111/j.1365-3148.2007.00802.x