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Porphyrinmaleimides: towards thiol probes for cysteine residues in proteins.
- Source :
-
Bioconjugate chemistry [Bioconjug Chem] 2008 Jan; Vol. 19 (1), pp. 5-9. Date of Electronic Publication: 2007 Dec 08. - Publication Year :
- 2008
-
Abstract
- Porphyrinmaleimides were synthesized and characterized. The thiol-containing amino acid L-cysteine reacted with 58% yield with these porphyrins to form bioconjugate adducts. The new thiol-active reagents were labeled cytoplasmic cysteine 140 and 316 in rhodopsin (Rh), a G protein coupled receptor (GPCR).
Details
- Language :
- English
- ISSN :
- 1043-1802
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioconjugate chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 18067244
- Full Text :
- https://doi.org/10.1021/bc700267f