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Synthesis study of 2'-O-(2-methoxyethyl)-purine derivatives.

Authors :
Sivets GG
Source :
Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2007; Vol. 26 (10-12), pp. 1237-40.
Publication Year :
2007

Abstract

Alkylation of adenosine and 2-aminoadenosine was studied in dimethylsulfoxide with application of 1-methanesulfonyloxy-2-methoxyethane as an alkylating agent and t-BuOK, KOH and NaH as bases under mild heating. Using new reaction conditions, the improved synthesis of 2'-O-MOE-purine derivatives is described.

Subjects

Subjects :
Alkylation
Ethane chemistry
Ethane analogs & derivatives
Purine Nucleosides chemical synthesis
Ribonucleosides chemical synthesis
Sulfinic Acids chemistry

Details

Language :
English
ISSN :
1525-7770
Volume :
26
Issue :
10-12
Database :
MEDLINE
Journal :
Nucleosides, nucleotides & nucleic acids
Publication Type :
Academic Journal
Accession number :
18066759
Full Text :
https://doi.org/10.1080/15257770701528180
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