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Activity-dependent plasticity in an olfactory circuit.
- Source :
-
Neuron [Neuron] 2007 Dec 06; Vol. 56 (5), pp. 838-50. - Publication Year :
- 2007
-
Abstract
- Olfactory sensory neurons (OSNs) form synapses with local interneurons and second-order projection neurons to form stereotyped olfactory glomeruli. This primary olfactory circuit is hard-wired through the action of genetic cues. We asked whether individual glomeruli have the capacity for stimulus-evoked plasticity by focusing on the carbon dioxide (CO2) circuit in Drosophila. Specialized OSNs detect this gas and relay the information to a dedicated circuit in the brain. Prolonged exposure to CO2 induced a reversible volume increase in the CO2-specific glomerulus. OSNs showed neither altered morphology nor function after chronic exposure, but one class of inhibitory local interneurons showed significantly increased responses to CO2. Two-photon imaging of the axon terminals of a single PN innervating the CO2 glomerulus showed significantly decreased functional output following CO2 exposure. Behavioral responses to CO2 were also reduced after such exposure. We suggest that activity-dependent functional plasticity may be a general feature of the Drosophila olfactory system.
- Subjects :
- Absorptiometry, Photon
Animals
Behavior, Animal drug effects
Brain anatomy & histology
Brain physiology
Carbon Dioxide metabolism
Carbon Dioxide pharmacology
Drosophila
Female
Fluorescent Antibody Technique
Interneurons drug effects
Interneurons physiology
Neuronal Plasticity drug effects
Neurons, Afferent physiology
Odorants
Olfactory Pathways anatomy & histology
Olfactory Pathways drug effects
Smell drug effects
Neuronal Plasticity physiology
Olfactory Pathways physiology
Smell physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0896-6273
- Volume :
- 56
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 18054860
- Full Text :
- https://doi.org/10.1016/j.neuron.2007.10.035