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Electrical impedance scanning as a new breast cancer risk stratification tool for young women.
Electrical impedance scanning as a new breast cancer risk stratification tool for young women.
- Source :
-
Journal of surgical oncology [J Surg Oncol] 2008 Feb 01; Vol. 97 (2), pp. 112-20. - Publication Year :
- 2008
-
Abstract
- Background: Electrical impedance scanning (EIS) measures changes in breast tissue associated with breast cancer (Br-Ca) development. The T-Scan(tm2000 (ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e., T-Scan+ women).<br />Aim: To estimate the relative probability of breast cancer in a T-Scan+ woman compared to a randomly selected young woman.<br />Methods: A prospective, two-cohort trial was conducted in pre-menopausal women. The Specificity (S(p))-Cohort evaluated T-Scan specificity in 1,751 asymptomatic women ages 30-39. The Sensitivity)S(n))-Cohort evaluated T-Scan sensitivity in 390 women ages 45-30 scheduled for biopsy. Specificity, sensitivity, and conservative estimate of disease prevalence were used to calculate relative probability.<br />Results: In the S(p)-Cohort, 93 of 1,751 women were T-Scan+ (S(p) = 94.7%; 95% CI: 93.7-95.7%). In the S(n)-Cohort, 23 of 87 biopsy-proven cancers were T-Scan+ (S(n) = 26.4%; 95% CI: 17.4-35.4%). Given S(p) = 94.7%, S(n) = 26.4% and prevalence of 1.5 cancers/1,000 women (ages 30-39), the relative probability of a T-Scan+ woman having Br-Ca is 4.95: (95% CI: 3.16-7.14).<br />Conclusion: EIS can identify a subset of young women with a relative probability of breast cancer almost five times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of Br-Ca to warrant further surveillance or imaging.
- Subjects :
- Adult
Biopsy
Cohort Studies
Electrodiagnosis instrumentation
Electrodiagnosis methods
Female
Humans
Middle Aged
Predictive Value of Tests
Premenopause physiology
Probability
Prospective Studies
Risk Assessment
Sensitivity and Specificity
Breast pathology
Breast Neoplasms diagnosis
Electric Impedance
Subjects
Details
- Language :
- English
- ISSN :
- 0022-4790
- Volume :
- 97
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 18050282
- Full Text :
- https://doi.org/10.1002/jso.20931