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[Infliximab in moderate to severe steroid-dependent or steroid-refractory ulcerative colitis].

[Infliximab in moderate to severe steroid-dependent or steroid-refractory ulcerative colitis].

Authors :
Mocciaro F
Orlando A
Scimeca D
Cottone M
Source :
Recenti progressi in medicina [Recenti Prog Med] 2007 Nov; Vol. 98 (11), pp. 560-4.
Publication Year :
2007

Abstract

Tumor Necrosis Factor alpha plays a main role in ulcerative colitis. Thirteen male and 8 female affected by moderate to severe steroid-dependent or refractory-severe ulcerative colitis were treated with 5 mg/kg of infliximab (Remicade). At 12 week efficacy, steroid-sparing, colectomy and side effects were evaluated. In steroid-dependent group (13 patients): 8 patients had a clinical benefit (7 obtained a clinical remission, 54%), 8 (61.5%) discontinued steroids, 1 patient underwent surgery. In steroid-severe refractory group (8 patients): 3 patients (37.5%) had a clinical remission, 2 (25%) had a clinical response and 3 (37.5%) underwent colectomy. One mild infusion reaction and one adverse event (itch) were observed. Infliximab is an effective and safe therapy in patients with moderate to severe steroid dependent and refractory ulcerative colitis.

Details

Language :
Italian
ISSN :
0034-1193
Volume :
98
Issue :
11
Database :
MEDLINE
Journal :
Recenti progressi in medicina
Publication Type :
Academic Journal
Accession number :
18044405