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Distribution of nonvestibular cranial nerve schwannomas in neurofibromatosis 2.
- Source :
-
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology [Otol Neurotol] 2007 Dec; Vol. 28 (8), pp. 1083-90. - Publication Year :
- 2007
-
Abstract
- Objective: To describe the prevalence and location of cranial nerve schwannomas, other than bilateral vestibular schwannoma, in patients with neurofibromatosis 2 (NF2). The NF2 Natural History Consortium prospectively gathered cranial magnetic resonance imaging for 83 patients across 3 annual evaluations. The time between the first and last evaluation was approximately 3 years.<br />Results: Forty-two patients (51%) had nonvestibular cranial nerve schwannomas (NVSs). Of these, 25 (60%) also had cranial meningiomas. Twenty-one of those without NVS (25% of 83) had at least 1 meningioma. The average size of the NVS was 0.4 cubic centimeters. Overall, there was no significant change in NVS size from Year 1 to Year 3 or from Year 1 to Year 2. The most common locations of the NVS were occulomotor and trigeminal. A family history of NF2 did not predict NVS location or growth.<br />Conclusion: Nonvestibular cranial nerve schwannoma usually affect cranial nerves III and V, as was the case in our NF2 sample. Fortunately, neuropathies associated with these tumors are rare. In contrast, lower cranial nerve schwannomas, although also rare, are associated with swallowing difficulty, aspiration, and other sequelae.
- Subjects :
- Adolescent
Adult
Cranial Nerve Neoplasms epidemiology
Cranial Nerve Neoplasms pathology
Cranial Nerves pathology
Disease Progression
Female
Genes, Neurofibromatosis 2 physiology
Humans
Magnetic Resonance Imaging
Male
Meningioma epidemiology
Meningioma etiology
Meningioma pathology
Neurilemmoma epidemiology
Neurilemmoma pathology
Neurofibromatosis 2 pathology
Oculomotor Nerve pathology
Trigeminal Nerve pathology
Cranial Nerve Neoplasms etiology
Neurilemmoma etiology
Neurofibromatosis 2 complications
Subjects
Details
- Language :
- English
- ISSN :
- 1531-7129
- Volume :
- 28
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
- Publication Type :
- Academic Journal
- Accession number :
- 18043434
- Full Text :
- https://doi.org/10.1097/MAO.0b013e31815a8411