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CD1 antigen presentation: how it works.
- Source :
-
Nature reviews. Immunology [Nat Rev Immunol] 2007 Dec; Vol. 7 (12), pp. 929-41. - Publication Year :
- 2007
-
Abstract
- The classic concept of self-non-self discrimination by the immune system focused on the recognition of fragments from proteins presented by classical MHC molecules. However, the discovery of MHC-class-I-like CD1 antigen-presentation molecules now explains how the immune system also recognizes the abundant and diverse universe of lipid-containing antigens. The CD1 molecules bind and present amphipathic lipid antigens for recognition by T-cell receptors. Here, we outline the recent advances in our understanding of how the processes of CD1 assembly, trafficking, lipid-antigen binding and T-cell activation are achieved and the new insights into how lipid antigens differentially elicit CD1-restricted innate and adaptive T-cell responses.
- Subjects :
- Animals
Antigens, CD1 chemistry
Carrier Proteins physiology
Cell Membrane metabolism
Crystallization
Dendritic Cells metabolism
Endocytosis
Endoplasmic Reticulum metabolism
Humans
Killer Cells, Natural immunology
Lipid Metabolism
Lipids immunology
Lymphocyte Activation
Protein Transport
Saponins pharmacology
Antigen Presentation immunology
Antigens, CD1 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1474-1741
- Volume :
- 7
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature reviews. Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18037897
- Full Text :
- https://doi.org/10.1038/nri2191