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Recognition memory: opposite effects of hippocampal damage on recollection and familiarity.
- Source :
-
Nature neuroscience [Nat Neurosci] 2008 Jan; Vol. 11 (1), pp. 16-8. Date of Electronic Publication: 2007 Nov 25. - Publication Year :
- 2008
-
Abstract
- A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.
- Subjects :
- Animals
Behavior, Animal
Brain Injuries physiopathology
Conditioning, Operant
Cues
Male
Odorants
Olfactory Pathways physiopathology
ROC Curve
Rats
Rats, Long-Evans
Brain Injuries pathology
Discrimination Learning physiology
Hippocampus physiopathology
Mental Recall physiology
Recognition, Psychology physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6256
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 18037884
- Full Text :
- https://doi.org/10.1038/nn2016