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NET-SYNTHESIS: a software for synthesis, inference and simplification of signal transduction networks.
- Source :
-
Bioinformatics (Oxford, England) [Bioinformatics] 2008 Jan 15; Vol. 24 (2), pp. 293-5. Date of Electronic Publication: 2007 Nov 22. - Publication Year :
- 2008
-
Abstract
- Unlabelled: We present a software for combined synthesis, inference and simplification of signal transduction networks. The main idea of our method lies in representing observed indirect causal relationships as network paths and using techniques from combinatorial optimization to find the sparsest graph consistent with all experimental observations. We illustrate the biological usability of our software by applying it to a previously published signal transduction network and by using it to synthesize and simplify a novel network corresponding to activation-induced cell death in large granular lymphocyte leukemia.<br />Availability: NET-SYNTHESIS is freely downloadable from http://www.cs.uic.edu/~dasgupta/network-synthesis/
Details
- Language :
- English
- ISSN :
- 1367-4811
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Bioinformatics (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 18033793
- Full Text :
- https://doi.org/10.1093/bioinformatics/btm571