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Historical review of BCG vaccine in Japan.
- Source :
-
Japanese journal of infectious diseases [Jpn J Infect Dis] 2007 Nov; Vol. 60 (6), pp. 331-6. - Publication Year :
- 2007
-
Abstract
- Bacillus Calmette and Guérin (BCG) was introduced to Japan in 1924 by Kiyoshi Shiga and has been propagated for research purposes ever since propagation is accomplished using a glycerin-bile-potato mixture in the same manner used by Calmette and Guérin. To prepare a stable and safe freeze-dried BCG vaccine, several joint research projects were organized in 1949. At the National Institute of Infectious Diseases (formerly the National Institute of Health), the 172nd passage of BCG from the first culture was freeze-dried in 1961 and was used as the origin of the Japanese BCG strain, Tokyo-172. The Tokyo-172 was registered as an International Reference Strain in 1965 by the World Health Organization. In 1967, a multiple puncture method for BCG vaccination using a plastic cylinder implanted with nine fine needles at one end was introduced to Japan; thereafter, percutaneous administration replaced intradermal injection. The efficacy and adverse reactions of BCG vaccines as well as recent knowledge on the genetic characterization of BCG is also discussed.
- Subjects :
- BCG Vaccine administration & dosage
BCG Vaccine adverse effects
BCG Vaccine standards
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Japan
Mycobacterium bovis genetics
Quality Control
Tuberculosis microbiology
Tuberculosis prevention & control
Vaccination history
Vaccination methods
BCG Vaccine history
Tuberculosis history
Subjects
Details
- Language :
- English
- ISSN :
- 1344-6304
- Volume :
- 60
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Japanese journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 18032829