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Low complement C4B gene copy number predicts short-term mortality after acute myocardial infarction.
- Source :
-
International immunology [Int Immunol] 2008 Jan; Vol. 20 (1), pp. 31-7. Date of Electronic Publication: 2007 Nov 20. - Publication Year :
- 2008
-
Abstract
- Background and Objectives: Some recent data indicate that risk of death after acute coronary syndrome is under genetic control. Previously, we found that the C4B*Q0 genotype (low copy number of the C4B gene that encodes the fourth component of complement) is strongly associated with morbidity and mortality of cardiovascular diseases (CVD). The +252 G allele of the lymphotoxin-alpha (LTA) gene encoded close to the C4B gene was also reported to be related to CVD-related mortality in an Oriental population.<br />Methods: The relationship between the copy number of the genes encoding the fourth component of complement (C4A and C4B) and LTA 252 single-nucleotide polymorphism (SNP) on the one hand and mortality after acute myocardial infarction (AMI) was studied in 142 Icelandic patients. The number of the C4A and C4B genes was determined in genomic DNA samples by a newly developed real-time PCR-based method; lymphotoxin-alpha (LTA) +252 A>G polymorphism was determined by PCR-restriction fragment length polymorphism analysis.<br />Results: The C4B*Q0 genotype was found to be strongly associated with 1-year mortality, with a hazard ratio of 3.50 (1.38-8.87) (P = 0.008) (adjusted Cox regression analysis). This association was, however, restricted to ever-smoking patients. By contrast, neither C4A gene copy numbers nor LTA 252 SNP did confer increased risk of mortality after AMI.<br />Conclusions: This observation indicates that low C4B copy number is a strong risk factor for short-term mortality after AMI in smoking Icelandic patients, whereas LTA 252 G allele is not a risk factor in Caucasian population.
- Subjects :
- Aged
Aged, 80 and over
Female
Humans
Iceland
Lymphotoxin-alpha genetics
Male
Polymerase Chain Reaction methods
Polymorphism, Single Nucleotide
Risk Factors
Survival Analysis
Complement C4b genetics
Gene Dosage
Genetic Predisposition to Disease
Myocardial Infarction genetics
Myocardial Infarction mortality
Smoking adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2377
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18032375
- Full Text :
- https://doi.org/10.1093/intimm/dxm117