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Development of high-sensitive DNA probe by using perylene.

Authors :
Kashida H
Takatsu T
Asanuma H
Source :
Nucleic acids symposium series (2004) [Nucleic Acids Symp Ser (Oxf)] 2007 (51), pp. 279-80.
Publication Year :
2007

Abstract

Modified oligodeoxyribonucleotides (ODNs) involving two perylene moieties are synthesized. By using this ODN, one-base deletion can easily be distinguished with high sensitivity. In addition, emission color of the solution greatly changed so that the detection was possible even by naked eyes.

Subjects

Subjects :
Oligodeoxyribonucleotides chemical synthesis
Oligodeoxyribonucleotides chemistry
Polymorphism, Single Nucleotide
Spectrometry, Fluorescence
DNA Probes chemistry
Fluorescent Dyes chemistry
Perylene chemistry
Polymorphism, Genetic

Details

Language :
English
ISSN :
1746-8272
Issue :
51
Database :
MEDLINE
Journal :
Nucleic acids symposium series (2004)
Publication Type :
Academic Journal
Accession number :
18029695
Full Text :
https://doi.org/10.1093/nass/nrm140
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