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Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes.
- Source :
-
European journal of haematology [Eur J Haematol] 2008 Feb; Vol. 80 (2), pp. 107-14. Date of Electronic Publication: 2007 Nov 17. - Publication Year :
- 2008
-
Abstract
- Objectives: An aberrant pattern of expression of L-selectin and intercellular adhesion molecule 1 (ICAM1) may characterise CD34+ blast cells in myelodysplastic syndromes (MDS) and secondary acute myeloid leukaemia (sAML).<br />Methods: In a three-colour flow cytometric assay, we evaluated the expression of L-selectin and ICAM1 on CD34+ blast cells from the bone marrow (BM) of 66 MDS patients; for the purpose of comparison CD34+ blast cells of 18 sAML and CD34+ stem cells of 17 normal donors were also analysed.<br />Results: The ratio of L-selectin/ICAM1 expression was identified as a parameter correlated with the percentage of BM blast infiltration and the time to leukaemic progression among MDS patients. In fact, the values of L-selectin/ICAM1 ratio were inversely correlated with the BM blast infiltration (r = -0.34, P = 0.004). Furthermore, MDS patients with a baseline ratio <1 had a higher leukaemic progression rate (41% vs. 19%, P = 0.008); the actuarial risk of disease progression for this subgroup of MDS patients was also higher (64% vs. 11% at 2 yr, P = 0.002). Furthermore, in two patients a decrease of the ratio was observed when overt leukaemic transformation occurred; conversely, restoration of a normal ratio was observed in two patients after a chemotherapy-induced remission.<br />Conclusion: (i) L-selectin is defective in the stem cell compartment of MDS and sAML, whereas ICAM1 is overexpressed; (ii) the ratio of their expression has a prognostic role; and (iii) a ratio <1 significantly predicts progression to overt leukaemia in MDS patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antigens, CD34 biosynthesis
Bone Marrow metabolism
Disease Progression
Female
Humans
Intercellular Adhesion Molecule-1 blood
L-Selectin blood
Leukemia, Myeloid, Acute diagnosis
Leukemia, Myeloid, Acute metabolism
Male
Middle Aged
Prognosis
Time Factors
Gene Expression Regulation
Intercellular Adhesion Molecule-1 biosynthesis
L-Selectin biosynthesis
Myelodysplastic Syndromes diagnosis
Myelodysplastic Syndromes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0609
- Volume :
- 80
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 18028430
- Full Text :
- https://doi.org/10.1111/j.1600-0609.2007.00986.x