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Role of Txk, a member of the Tec family of tyrosine kinases, in immune-inflammatory diseases.
- Source :
-
International reviews of immunology [Int Rev Immunol] 2007 Sep-Dec; Vol. 26 (5-6), pp. 333-48. - Publication Year :
- 2007
-
Abstract
- Txk/Rlk, a member of the Tec family of tyrosine kinases, is an important signaling mediator. We previously reported that human Txk is expressed in Th1/Th0 cells, and Txk translocates from cytoplasm into nuclei upon activation. Txk regulates specifically interferon-gamma gene transcription. Txk, poly(ADP-ribose) polymerase 1, and elongation factor 1alpha make a complex to bind to interferon-gamma gene promoter region-53/-39 (Txk responsive element) to exert positive effects on transcription as a Th1 cell-associated transcription factor. Txk expression is enhanced in rheumatoid arthritis and Behçet's disease, where Th1 dominant immunity occurs. In bronchial asthma and atopic dermatitis, typical Th2 diseases, Txk expression is reduced. Modulation of Txk expression by gene transfer or similar modality may lead to the correction of aberrant immunity and, consequently, disease treatment.
- Subjects :
- Animals
Cytokines immunology
Humans
Hypersensitivity, Immediate immunology
Hypersensitivity, Immediate metabolism
T-Lymphocyte Subsets immunology
Cytokines metabolism
Hypersensitivity, Immediate enzymology
Inflammation enzymology
Protein-Tyrosine Kinases genetics
Protein-Tyrosine Kinases metabolism
T-Lymphocyte Subsets enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0883-0185
- Volume :
- 26
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- International reviews of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 18027204
- Full Text :
- https://doi.org/10.1080/08830180701690835