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Incidence of bacteremias and invasive mycoses in children undergoing allogeneic hematopoietic stem cell transplantation: a single center experience.

Authors :
Castagnola E
Bagnasco F
Faraci M
Caviglia I
Caruso S
Cappelli B
Moroni C
Morreale G
Timitilli A
Tripodi G
Lanino E
Haupt R
Source :
Bone marrow transplantation [Bone Marrow Transplant] 2008 Feb; Vol. 41 (4), pp. 339-47. Date of Electronic Publication: 2007 Nov 19.
Publication Year :
2008

Abstract

We performed a retrospective single center study to define the epidemiology of bacteremias or invasive mycoses in pediatric allogeneic hematopoietic SCT (HSCT) from matched related donors (MRD) or alternative donors (AD). During 119 213 days of follow-up, 156 infections were observed: 130 bacteremias (27 in MRD-HSCT and 103 in AD-HSCT recipients) and 26 invasive mycoses (8 in MRD-HSCT and 18 in AD-HSCT recipients). Overall, the risk of bacteremia was fivefold that of invasive mycosis (P<0.001). AD-HSCT recipients had a higher percentage of infections (89 vs 27%; P<0.001), a higher rate/100 days of immunosuppression (infection rate (IR): 0.21 vs 0.06; P<0.001) and a higher proportion of repeated infections (44 vs 9%; P=0.001). In AD-HSCT, the relative risk of bacteremia was 2.87 in the pre-engraftment period, 5.84 in the early post-engraftment period and 6.46 in the late post-engraftment period (P<0.001) compared to MRD-HSCT. Only after 1 year did the epidemiology become similar. The epidemiology of invasive mycoses did not differ significantly between the two types of transplant.

Details

Language :
English
ISSN :
0268-3369
Volume :
41
Issue :
4
Database :
MEDLINE
Journal :
Bone marrow transplantation
Publication Type :
Academic Journal
Accession number :
18026151
Full Text :
https://doi.org/10.1038/sj.bmt.1705921