No relation between angiotensin-converting enzyme gene polymorphism and pseudoexfoliation.

Authors :: Tekeli O
Turaçli ME
Altinok B
Akar N
Elhan AH
Source :: Ophthalmic research [Ophthalmic Res] 2008; Vol. 40 (1), pp. 32-4. Date of Electronic Publication: 2006 Nov 27.
Publication Year :: 2008
Abstract: Aims: To determine the association between the angiotensin-converting enzyme insertion/deletion (I/D) polymorphism and pseudoexfoliation (PEX) in Turkish patients.<br />Methods: This prospective study consisted of 89 patients with PEX, and 120 controls. The I/D polymorphism of the angiotensin-converting enzyme gene was measured with the use of the polymerase chain reaction method.<br />Results: The distribution of the polymorphism was not significantly different in cases with PEX and controls. The frequencies of the I and D alleles were not significantly different between the groups.<br />Conclusion: According to our findings, I/D polymorphism in the angiotensin-converting enzyme gene does not play any role in the pathogenesis of PEX.

Subjects :: Aged
DNA Transposable Elements
Female
Gene Deletion
Gene Frequency
Humans
Male
Middle Aged
Polymerase Chain Reaction
Exfoliation Syndrome genetics
Peptidyl-Dipeptidase A genetics
Polymorphism, Genetic

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