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In vitro activity of RU29246. The metabolite of a new HR916 cephalosporin ester.
- Source :
-
Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 1991 Nov-Dec; Vol. 14 (6), pp. 473-83. - Publication Year :
- 1991
-
Abstract
- Compound RU29246 (RU) is the active metabolite of an orally absorpted cephalosporin ester HR916. The RU spectrum of activity includes the majority of Enterobacteriaceae species, Haemophilus influenzae, pathogenic Neisseria spp., Moraxella catarrhalis, Acinetobacter antiratus, staphylococci, and Streptococcus spp. Pseudomonas species and enterococci were routinely resistant to RU. The RU spectrum was most similar to cefixime against the Gram-negative bacilli and to cefuroxime against the Gram-positive organisms. RU was bactericidal and its mean inhibitory concentrations (MICs) were not greatly increased by high inoculum concentrations. Many strains producing various beta-lactamases generally remained susceptible to RU by MIC tests. However, isolates with extended broad spectrum beta-lactamases capable of hydrolyzing cefotaxime and ceftazidime were also resistant to RU. Broth and agar RU MICs were comparable. Its activity was increased against enterococci in the presence of blood products.
- Subjects :
- Anti-Bacterial Agents chemistry
Cephalosporins chemistry
Drug Resistance, Microbial
Gram-Negative Bacteria enzymology
Gram-Positive Bacteria enzymology
Humans
Microbial Sensitivity Tests
Molecular Structure
beta-Lactamases metabolism
Anti-Bacterial Agents pharmacology
Cephalosporins pharmacology
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0732-8893
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Diagnostic microbiology and infectious disease
- Publication Type :
- Academic Journal
- Accession number :
- 1802534
- Full Text :
- https://doi.org/10.1016/0732-8893(91)90003-x