Back to Search
Start Over
Chronic valproate normalizes behavior in mice overexpressing calcineurin.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2008 Feb 02; Vol. 580 (1-2), pp. 153-60. Date of Electronic Publication: 2007 Oct 25. - Publication Year :
- 2008
-
Abstract
- Calcineurin (PP2B) is a Ca(2+)-dependent protein phosphatase enriched in the brain that takes part in intracellular signaling pathways regulating synaptic plasticity and complex brain functions. We report here that when these pathways are activated by transgenic expression of calcineurin, locomotor activity of mice in response to novelty is increased, as well as the behavioral and molecular responses of the psychostimulant cocaine. We also observed that the anxious-like behavior is altered. These behavioral changes are indicative of a generally increased behavioral responsiveness and could be normalized by chronic treatment with the mood stabilizer valproate. These results provide proof of concept that calcineurin-dependent dephosphorylation plays an important role in behavioral reactivity and in the effects of mood regulators. Mice overexpressing calcineurin represent a novel tool to study affective responses related to psychiatric disorders.
- Subjects :
- Animals
Antimanic Agents administration & dosage
Calcineurin genetics
Cocaine pharmacology
Disease Models, Animal
Gene Expression
Maze Learning drug effects
Mice
Mice, Transgenic
Mood Disorders drug therapy
Motor Activity drug effects
Phosphorylation drug effects
Valproic Acid administration & dosage
Antimanic Agents pharmacology
Behavior, Animal drug effects
Calcineurin metabolism
Valproic Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 580
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 18021766
- Full Text :
- https://doi.org/10.1016/j.ejphar.2007.10.050