AFM study of a new carrier based on PLA and salen copolymers for gene therapy.

Authors :: Nadeau V
Hildgen P
Source :: Molecules (Basel, Switzerland) [Molecules] 2005 Jan 31; Vol. 10 (1), pp. 105-13. Date of Electronic Publication: 2005 Jan 31.
Publication Year :: 2005
Abstract: The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.