Total synthesis and absolute configuration of laurenditerpenol: a hypoxia inducible factor-1 activation inhibitor.

Authors :: Chittiboyina AG
Kumar GM
Carvalho PB
Liu Y
Zhou YD
Nagle DG
Avery MA
Source :: Journal of medicinal chemistry [J Med Chem] 2007 Dec 13; Vol. 50 (25), pp. 6299-302. Date of Electronic Publication: 2007 Nov 16.
Publication Year :: 2007
Abstract: The absolute stereo structure of the natural product laurenditerpenol (1S, 6R, 7S, 10R, 11R, 14S, 15R) has been accomplished from eight plausible stereoisomers by its first asymmetric total synthesis in a highly convergent and flexible synthetic pathway. Six stereoisomers of laurenditerpenol were synthesized and evaluated for their biological activity.

Subjects :: Cell Hypoxia
Cell Line, Tumor
Diterpenes chemistry
Diterpenes pharmacology
Humans
Hypoxia-Inducible Factor 1 biosynthesis
Molecular Conformation
Stereoisomerism
Structure-Activity Relationship
Diterpenes chemical synthesis
Hypoxia-Inducible Factor 1 antagonists & inhibitors

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