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Induction of heat shock proteins in lymphocytes increases with mitogen stimulation.
- Source :
-
Immunology letters [Immunol Lett] 1991 Nov; Vol. 30 (3), pp. 333-7. - Publication Year :
- 1991
-
Abstract
- The effect of the growth state of a cell on the ability of hyperthermia to induce the synthesis of heat shock proteins (HSPs) was studied in resting and concanavalin A (ConA)-stimulated lymphocytes. Hyperthermia induced the synthesis of hsp 110, hsp 90, hsc 70, and hsp 70 in both resting and ConA-stimulated lymphocytes, and ConA-treatment induced the synthesis of the hsp 90 and hsc 70 at normal temperature. The induction of the synthesis of hsp 110 and hsp 70 by hyperthermia was 3- to 6-fold higher for lymphocytes cultured with ConA for 12 and 24 h than in non-stimulated lymphocytes. Thus, lymphocytes induced to undergo proliferation showed a greater response to hyperthermia than resting lymphocytes.
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 30
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 1800319
- Full Text :
- https://doi.org/10.1016/0165-2478(91)90047-e