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Mass spectrometric detection of urinary oligosaccharides as markers of Schistosoma mansoni infection.
- Source :
-
Transactions of the Royal Society of Tropical Medicine and Hygiene [Trans R Soc Trop Med Hyg] 2008 Jan; Vol. 102 (1), pp. 79-83. Date of Electronic Publication: 2007 Nov 09. - Publication Year :
- 2008
-
Abstract
- Current diagnosis of schistosomiasis is still not ideal. In the present study we evaluated a targeted affinity approach using mAb 114-4D12, reactive with a unique Schistosoma mansoni-specific glycan epitope, combined with matrix-assisted laser-desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry. For nine of 11 urine samples (1ml) from Egyptian individuals with different intensities of infection, a characteristic MALDI-TOF mass spectrum was observed, representing a series of fuco-oligosaccharides that are produced by schistosome eggs. The identification of these small molecule markers may lead to a new egg-load-related assay for light infections in schistosomiasis.
Details
- Language :
- English
- ISSN :
- 0035-9203
- Volume :
- 102
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Transactions of the Royal Society of Tropical Medicine and Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 17996914
- Full Text :
- https://doi.org/10.1016/j.trstmh.2007.09.017