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Synthesis, characterization, antifungal and anti-HIV activities of metal(II) complexes of 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2008 Jul; Vol. 43 (7), pp. 1536-42. Date of Electronic Publication: 2007 Oct 05. - Publication Year :
- 2008
-
Abstract
- Co(II) and Ni(II) complexes with 4,6-di-tert-butyl-3-[(2-hydroxyethyl)thio]benzene-1,2-diol (L) have been synthesized and characterized by means of elemental analysis, TG/DTA, FT-IR, ESR, UV-vis, XRD, magnetic susceptibility, cyclic voltammetry and conductance measurements. According to the data obtained the organic compound acts as a bidentate O,S-coordinated ligand and yields Co(II) and Ni(II) complexes of the stoichiometry ML(2) which is characterized by square planar geometry. Antifungal and anti-HIV activities of the ligand and its metal(II) complexes were found to decrease in the sequence CuL(2)>CoL(2) ~ NiL(2)>HL, along with their reducing ability (determined electrochemically).
Details
- Language :
- English
- ISSN :
- 0223-5234
- Volume :
- 43
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 17996335
- Full Text :
- https://doi.org/10.1016/j.ejmech.2007.09.024