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Molecular epidemiology of rabies virus isolated from different sources during a bat-transmitted human outbreak occurring in Augusto Correa municipality, Brazilian Amazon.
- Source :
-
Virology [Virology] 2008 Jan 20; Vol. 370 (2), pp. 228-36. Date of Electronic Publication: 2007 Nov 08. - Publication Year :
- 2008
-
Abstract
- We genetically characterize rabies virus (RABV) strains isolated from human cases, domestic and wild animals during a human outbreak of bat-transmitted rabies in Augusto Correa municipality, Pará state, Brazilian Amazon in 2005. Partial nucleotide sequences of the N gene (491 bp) were obtained for all strains, and phylogenetic analysis grouped these into two major clades (Pará and Central-Southeast) and identified them as bat-related viruses genotype I, Desmodus rotundus antigenic variant 3 (AgV3). A molecular clock was used to estimate the time of emergence for each RABV isolate. The molecular data from this study suggest the association of vampire bats with human and domestic animal cases reported in the outbreak, the circulation of at least two predominant lineages in the Pará state, and also a geographic association to lineages dispersion.
- Subjects :
- Adolescent
Adult
Animals
Base Sequence
Brazil epidemiology
Child
DNA Primers genetics
DNA, Viral genetics
Disease Vectors
Female
Genes, Viral
Humans
Male
Middle Aged
Molecular Epidemiology
Nucleocapsid Proteins genetics
Phylogeny
Rabies transmission
Rabies virus classification
Time Factors
Chiroptera virology
Disease Outbreaks
Rabies epidemiology
Rabies virology
Rabies virus genetics
Rabies virus isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 0042-6822
- Volume :
- 370
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 17996263
- Full Text :
- https://doi.org/10.1016/j.virol.2007.10.005