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C7*N is a hypomorphic allele of the human complement c7 M/N protein polymorphism.
- Source :
-
Experimental and clinical immunogenetics [Exp Clin Immunogenet] 1991; Vol. 8 (3), pp. 177-83. - Publication Year :
- 1991
-
Abstract
- Two complement C7 protein polymorphisms exist. One is determined by isoelectric focussing whereas the other is determined by the reaction pattern of a monoclonal C7-allospecific antibody in an ELISA assay. C7 concentrations quantitated by an ELISA based on polyclonal C7-specific IgG and data from functional haemolytic assays were compared with the allotypes of both C7 protein polymorphisms. Testing a randomly selected Japanese population revealed that not only C7*3 but also C7*N is a hypomorphic allele. However, no significant disease association of C7*N or C7*M was found in studies of hospitalized patients.
Details
- Language :
- English
- ISSN :
- 0254-9670
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Experimental and clinical immunogenetics
- Publication Type :
- Academic Journal
- Accession number :
- 1799459