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[Association of methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency in malaria patients treated with primaquine].
- Source :
-
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2007 Sep-Oct; Vol. 40 (5), pp. 533-6. - Publication Year :
- 2007
-
Abstract
- This study had the aim of investigating occurrences of methemoglobinemia among individuals with glucose-6-phosphate dehydrogenase deficiency during treatment for malaria infection using primaquine. Patients with a diagnosis of malaria caused by Plasmodium vivax or the V+F mixture (Plasmodium vivax + Plasmodium falciparum) were selected. Group 1 consisted of 74 individuals with a clinical diagnosis of methemoglobinemia and Group 2 consisted of 161 individuals without a clinical diagnosis of methemoglobinemia. The glucose-6-phosphate dehydrogenase deficiency rates (numbers of enzymopenic individuals) in Groups 1 and 2 were 51.3% (38) and 8.7% (14) respectively. These data demonstrated a statistically significant association with methemoglobinemia only among the individuals in Group 1 (p<0.05). Investigation of the relationship between methemoglobinemia and glucose-6-phosphate dehydrogenase deficiency showed that there was a possible association such that enzymopenic individuals may develop methemoglobinemia more frequently.
- Subjects :
- Adolescent
Adult
Aged
Antimalarials therapeutic use
Child
Child, Preschool
Female
Glucosephosphate Dehydrogenase Deficiency diagnosis
Humans
Malaria, Falciparum enzymology
Malaria, Vivax enzymology
Male
Methemoglobinemia complications
Methemoglobinemia diagnosis
Middle Aged
Primaquine therapeutic use
Antimalarials adverse effects
Glucosephosphate Dehydrogenase Deficiency complications
Malaria, Falciparum drug therapy
Malaria, Vivax drug therapy
Methemoglobinemia chemically induced
Primaquine adverse effects
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 0037-8682
- Volume :
- 40
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revista da Sociedade Brasileira de Medicina Tropical
- Publication Type :
- Academic Journal
- Accession number :
- 17992408
- Full Text :
- https://doi.org/10.1590/s0037-86822007000500008