Preclinical evaluation of 99m technetium-labeled DD-3B6/22 Fab' for thrombus detection.

Authors :: Walker KZ
Boniface GR
Phippard AF
Harewood W
Bautovich GJ
Bundesen PG
Source :: Thrombosis research [Thromb Res] 1991 Dec 15; Vol. 64 (6), pp. 691-701.
Publication Year :: 1991
Abstract: Injection of 99mTc-labeled Fab' fragments of the anti-fibrin antibody DD-3B6/22, in the baboon, resulted in clear visualisation of both fresh and aged autologous thrombi by gamma scintigraphy. Whole body scintigraphy, pharmacokinetics and urine analysis showed rapid renal excretion of the conjugate with little accumulation of label in other organs. 99mTc-DD-3B6/22 Fab' appears a suitable candidate for further investigation as a radioimaging agent for thrombi in humans.

Subjects :: Animals
Drug Evaluation, Preclinical
Male
Papio
Phlebography
Radioimmunodetection
Thrombosis metabolism
Fibrin Fibrinogen Degradation Products immunology
Immunoglobulin Fab Fragments
Technetium pharmacokinetics
Thrombosis diagnosis

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