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The neural correlates of implicit sequence learning in schizophrenia.
- Source :
-
Neuropsychology [Neuropsychology] 2007 Nov; Vol. 21 (6), pp. 761-77. - Publication Year :
- 2007
-
Abstract
- Twenty-seven schizophrenia spectrum patients and 25 healthy controls performed a probabilistic version of the serial reaction time task (SRT) that included sequence trials embedded within random trials. Patients showed diminished, yet measurable, sequence learning. Postexperimental analyses revealed that a group of patients performed above chance when generating short spans of the sequence. This high-generation group showed SRT learning that was similar in magnitude to that of controls. Their learning was evident from the very 1st block; however, unlike controls, learning did not develop further with continued testing. A subset of 12 patients and 11 controls performed the SRT in conjunction with positron emission tomography. High-generation performance, which corresponded to SRT learning in patients, correlated to activity in the premotor cortex and parahippocampus. These areas have been associated with stimulus-driven visuospatial processing. Taken together, these results suggest that a subset of patients who showed moderate success on the SRT used an explicit stimulus-driven strategy to process the sequential stimuli. This adaptive strategy facilitated sequence learning but may have interfered with conventional implicit learning of the overall stimulus pattern.<br /> (PsycINFO Database Record (c) 2007 APA, all rights reserved.)
Details
- Language :
- English
- ISSN :
- 0894-4105
- Volume :
- 21
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuropsychology
- Publication Type :
- Academic Journal
- Accession number :
- 17983290
- Full Text :
- https://doi.org/10.1037/0894-4105.21.6.761