Rheumatoid arthritis association at 6q23.

Authors :: Thomson W
Barton A
Ke X
Eyre S
Hinks A
Bowes J
Donn R
Symmons D
Hider S
Bruce IN
Wilson AG
Marinou I
Morgan A
Emery P
Carter A
Steer S
Hocking L
Reid DM
Wordsworth P
Harrison P
Strachan D
Worthington J
Source :: Nature genetics [Nat Genet] 2007 Dec; Vol. 39 (12), pp. 1431-3. Date of Electronic Publication: 2007 Nov 04.
Publication Year :: 2007
Abstract: The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-5) - 5 x 10(-7) in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3).