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Clinicopathological study of nonalcoholic fatty liver disease in Japan: the risk factors for fibrosis.
- Source :
-
Liver international : official journal of the International Association for the Study of the Liver [Liver Int] 2008 Apr; Vol. 28 (4), pp. 519-24. Date of Electronic Publication: 2007 Nov 01. - Publication Year :
- 2008
-
Abstract
- Background/aims: We evaluated patients with nonalcoholic fatty liver disease (NAFLD) and compared the clinical and pathological features to identify the risk factors for NAFLD with severe fibrosis.<br />Methods: One hundred and eighty-two patients with biopsy-confirmed NAFLD from various medical centres were recruited into this study.<br />Results: The variables that were significantly associated with severe steatosis were male gender (mild:severe=36%:53%, P=0.02), younger age (mild:severe=57%:82%, P>0.001) and absence of type 2 diabetes (mild:severe=43%:71%, P>0.001). There was no significant difference in the degree of inflammation among the clinical groups. The variables that were significantly associated with severe fibrosis were female gender (mild:severe=54%:84%, P=0.002), older age (> or = 60 years old) (mild:severe=29%:53%, P=0.020), type 2 diabetes (mild:severe=42%:71%, P=0.020) and hypertension (mild:severe=24%:53%, P=0.002). Although there were more obese patients in the group with severe fibrosis, the association was not statistically significant (mild:severe=67%:78%, P=0.229). The prevalence of high serum triglyceride levels was similar between the two groups. The N (Nippon) score (total number of risk factor) could significantly predict severe fibrosis in NAFLD patients (1.48 +/- 1.14 vs. 2.66 +/- 0.94, P<0.001).<br />Conclusions: The N score can be used to predict severe fibrosis in cases of NAFLD.
- Subjects :
- Age Distribution
Aged
Alanine Transaminase blood
Biopsy, Needle
Disease Progression
Fatty Liver physiopathology
Female
Humans
Immunohistochemistry
Incidence
Japan epidemiology
Liver Cirrhosis physiopathology
Liver Function Tests
Male
Middle Aged
Predictive Value of Tests
Probability
Prognosis
ROC Curve
Retrospective Studies
Risk Assessment
Severity of Illness Index
Sex Distribution
Fatty Liver epidemiology
Fatty Liver pathology
Liver Cirrhosis epidemiology
Liver Cirrhosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-3231
- Volume :
- 28
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Liver international : official journal of the International Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 17976158
- Full Text :
- https://doi.org/10.1111/j.1478-3231.2007.01614.x