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Concise construction of novel bridged bicyclic lactams by sequenced Ugi/RCM/Heck reactions.
- Source :
-
Organic letters [Org Lett] 2007 Nov 22; Vol. 9 (24), pp. 5119-22. Date of Electronic Publication: 2007 Nov 01. - Publication Year :
- 2007
-
Abstract
- Herein we report a concise protocol for the diastereoselective synthesis of novel bridged bicyclic lactams from commercially available components by the sequence of Ugi, ring-closing metathesis (RCM), and Heck reactions. X-ray diffraction studies revealed that the bicyclic products contain varying degrees of pyramidalization of the bridgehead nitrogen atom.
Details
- Language :
- English
- ISSN :
- 1523-7060
- Volume :
- 9
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 17973488
- Full Text :
- https://doi.org/10.1021/ol7023373