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Effectiveness of stereotactic body radiotherapy in the treatment of inoperable early-stage lung cancer.
- Source :
-
Anticancer research [Anticancer Res] 2007 Sep-Oct; Vol. 27 (5B), pp. 3615-9. - Publication Year :
- 2007
-
Abstract
- Background: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide. Stereotactic body irradiation offers a non-invasive treatment modality for patients with early stage NSCLC who are not amenable to surgery or other invasive approaches because of their poor medical condition.<br />Patients and Methods: Forty-three inoperable patients with NSCLC were treated with SBRT at our institution. A mean total dose of 30.5 Gy in 1-4 fractions was applied. The median follow-up duration was 14 months (range 6-36 months).<br />Results: The actuarial survival at two years was 53%: two patients died from cancer progression whereas a further 8 patients died from comorbidities. Acute toxicity was practically absent, with 7 (16.3%) patients suffering from grade 1 symptoms and two from (4.6%) grade II effects. At the time of this report, only 1 patient had grade II and 6 patients (13.9%) grade I chronic symptoms.<br />Conclusion: Our results compare favourably with recently published studies and confirm that stereotactic radiotherapy has the potential to produce high local control rates with a low risk of lung toxicity in patients not amenable to curative resection. The low grade of side-effects is encouraging for shortening the treatment using a greater dose per fraction.
- Subjects :
- Aged
Aged, 80 and over
Disease-Free Survival
Female
Humans
Lung Neoplasms diagnosis
Lung Neoplasms epidemiology
Lung Neoplasms pathology
Male
Middle Aged
Morbidity
Neoplasm Staging
Prognosis
Radiosurgery adverse effects
Radiotherapy Dosage
Treatment Outcome
Lung Neoplasms surgery
Radiosurgery methods
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 27
- Issue :
- 5B
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 17972525