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[Effects of BCG-PSN injection on immune and lung function of asthmatic children complicated with allergic rhinitis].
- Source :
-
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology [Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi] 2007 Sep; Vol. 21 (3), pp. 279-81. - Publication Year :
- 2007
-
Abstract
- Objective: To investigate the effect of polysaccharide nucleic acid of BCG (BCG-PSN) injection on immune and pulmonary function in asthmatic children complicated with allergic rhinitis.<br />Methods: Thirty-seven cases were separated at random into two groups, the BCG-PSN group (17 cases) was treated with BCG-PSN plus inhaled glucocortisteriods, and the control group (20 cases) was treated with inhaled glucocortisteriods only. The children in both groups were followed up for 6 months to record their lung function, allergic rhinitis scores, frequency of asthmatic attacks and respiratory infection. The levels of interleukin (IL)-4, interferon-gamma (IFN-g) and plasma total IgE were detected by using double antibody sandwich ELISA at the beginning and the end of treatment.<br />Results: In comparison with the control group, after treatment, the levels of IFN-g and the ratio of IFN-g/IL4 in the BCG-PSN group significantly increased, whereas the level of IL-4 and the plasma total IgE significantly decreased (P less than 0.05), while those of the control group had no significant change. The lung function of both groups had significant improvement (p less than 0.05). The frequencies of asthmatic attacks in BCG-PSN and control groups were 0.81 +/- 0.20 vs. 1.72 +/- 0.80, and the difference was statistically significant. The frequencies of respiratory tract infection in BCG-PSN and control groups were 1.15 +/- 0.55 vs. 3.21 +/- 0.73, the difference was significant.<br />Conclusion: BCG-PSN may be able to correct the imbalance of Th1/Th2 and improve the lung function of children with asthma complicated with allergic rhinitis, which suggest that the immune adjusting treatment should be emphasized besides anti-inflammation therapy.
- Subjects :
- Adjuvants, Immunologic chemistry
Adjuvants, Immunologic therapeutic use
Adolescent
Asthma blood
Asthma complications
BCG Vaccine chemistry
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay methods
Female
Humans
Interferon-gamma blood
Interleukin-4 blood
Male
Nucleic Acids chemistry
Polysaccharides, Bacterial chemistry
Rhinitis, Allergic, Perennial blood
Rhinitis, Allergic, Perennial complications
Treatment Outcome
Asthma drug therapy
BCG Vaccine therapeutic use
Rhinitis, Allergic, Perennial drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-9279
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
- Publication Type :
- Academic Journal
- Accession number :
- 17971946