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[Expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance].
- Source :
-
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2007 Aug; Vol. 21 (15), pp. 692-4. - Publication Year :
- 2007
-
Abstract
- Objective: To evaluate expressions of NF-kappaB p65 in laryngeal carcinoma and normal mucous membrane and its clinical significance.<br />Method: The immunohistochemical method and the in situ hybridization were employed in detecting the NF-kappaB p65 expressions in surgical specimen from 48 laryngeal carcinoma and 20 normal mucous membrane.<br />Result: (1) The expression of NF kappaB p65 was higher than in normal laryngeal mucous membrane. (2) Positive expression of NF-kappaB p65 correlated with the development of distant metastasis.<br />Conclusion: The results of the study show that the NF-kappaB p65 protein is a significant predictor of survival in laryngeal carcinoma patients.
- Subjects :
- Adult
Aged
Carcinoma, Squamous Cell pathology
Case-Control Studies
Female
Humans
Laryngeal Mucosa pathology
Laryngeal Neoplasms pathology
Male
Middle Aged
Mucous Membrane metabolism
Mucous Membrane pathology
Neoplasm Staging
Young Adult
Carcinoma, Squamous Cell metabolism
Laryngeal Mucosa metabolism
Laryngeal Neoplasms metabolism
Transcription Factor RelA metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 2096-7993
- Volume :
- 21
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
- Publication Type :
- Academic Journal
- Accession number :
- 17969521